Collins 2022.

Study name	EVITA Dengue
Methods	Status: ongoing Aim: to determine the effectiveness of wMel mosquitoes in reducing the transmission of DENV, ZIKV, and CHIKV as indicated by the annual incidence of infection by these arboviruses Study type: cRCT Study dates: September 2020 to January 2025 Country, location: Brazil, urban Unit of allocation: community Number of units: 58 Length of follow‐up: ongoing
Participants	Number of participants: 3480 Method of recruitment: enrolled via eligible elementary schools Loss to follow‐up: N/I ongoing Age: 6–11 years at enrollment Sex: N/I ongoing Socio‐economic status: N/I ongoing
Interventions	Wolbachia species: wMel Mosquito species: Ae aegypti Mosquito life stage at release: adult Strategy: population replacement Number of deployments: 5.5 mosquitoes/person/week Timing of deployments: 16‐week establishment phase, then 16‐week consolidation phase Location of deployments: N/I ongoing Aimed % vector population replacement: > 60% population replacement Achieved % vector population replacement: N/I ongoing Field monitoring strategy: N/I ongoing Co‐interventions: standard mosquito control for the area
Outcomes	Primary outcome: dengue infection incidence Secondary outcome: Wolbachia population replacement
Starting date	28 July 2022
Contact information	Lee Ching Ng E‐mail: NG_Lee_Ching@nea.gov.sg
Notes