Risk of bias for analysis 1.1 All serotypes.

Study

Bias

Randomisation process

Deviations from intended interventions

Missing outcome data

Measurement of the outcome

Selection of the reported results

Overall

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Subgroup 1.1.1 All serotypes

Utarini 2021

Low risk of bias

Allocation sequence random and concealed. Imbalances in baseline characteristics appeared compatible with chance.

Low risk of bias

Unblinded study, but since participants were recruited upon presentation with symptoms, it is unlikely that this would affect the results. No deviations from intended interventions occurred.

Low risk of bias

No missing outcome data.

Low risk of bias

Appropriate measurement of the outcome performed with participants classified as having VCD if plasma sample obtained at enrollment was positive for dengue virus by reverse transcription polymerase chain reaction (RT‐PCR) or enzyme‐linked immunosorbent assay (ELISA).

Low risk of bias

Outcomes were reported as per the published protocol and prospective trial registry.

Low risk of bias

Domain 1b: risk of bias arising from the timing of identification or recruitment of participants was also judged to be at low risk of bias. Randomization was performed after community‐level consent to participate to minimize the likelihood that a cluster declines the deployments. The test‐negative design used means individual participants were not formally recruited. Overall low risk of bias.