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Evaluation of the efficacy and safety of Gd-HPMA12 on mice. A, B: T1-weighted MR images and the corresponding pseudo-color images of 4T1 tumor-bearing mice after intravenous injection of Gd-HPMA12 (CGd = 5.0 mg/kg) at different time intervals observed by a 3.0 T MRI scanner. C: ΔSNR for the MRI images A, B of tumors from 4T1 tumor-bearing mice post-injection of Gd-HPMA12 at different time intervals. Gd dosage = 5.0 mg/kg. Mean ± SD, n = 3
