Fig. 1.

Serum inflammatory protein landscape in breast cancer. Heatmaps visualizing unsupervised hierarchical clustering of the immuno-oncological serum proteins in the discovery (A) and validation (B) cohorts. The data are Z score-normalized relative protein levels. Blue denotes lower protein levels, and reddish denotes higher protein levels. Rows represent proteins, and columns represent samples from breast cancer patients and nonmalignant controls. Clinical variables are annotated on the top of the heatmaps, and their distribution between the inflamed and non-inflamed clusters was assessed by Fisher’s exact test. Dg, diagnosis; na, not assigned; TNBC, triple-negative breast cancer