Fig 8.

IFN-λ signaling in neutrophils contributes to protection from severe HSV-1 skin disease. Eight- to twelve-week-old male and female WT, Ifnlr1^−/−, LysM-Cre-Ifnlr1^−/−, and Mrp8-Cre-Ifnlr1^−/− mice were infected with 10⁶ FFU of HSV-1. (A) Dermatome skin lesions were photographed at 6 dpi. (B) Skin lesion areas were measured from photographs at 6 dpi using ImageJ. (C) Skin lesion severity was categorized based on the 6 dpi lesion area. Differences in lesion area and viral load were compared by the Mann-Whitney U test. Differences in categorical skin disease were compared by the Cochran-Armitage test. P values are reported with P < 0.05 considered to be statistically significant. Data are combined from three to four independent experiments per genotype.