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When to skip or discontinue IL-2 based on absolute or relative criteria*
| Observation category | Action |
| <3 relative criteria | Initiate corrective measure±skip IL-2 |
| ≥3 relative criteria | Initiate corrective measures, skip IL-2; Stop IL-2 if not reversible |
| Any absolute criteria | Initiate corrective measures, skip IL-2; Stop IL-2 if not reversible |
*Absolute and relative criteria are detailed in Table 3.
