Table 3.
Perinatal outcomes and gestational age at birth of singleton pregnancies, focusing on babies that survived
| Perinatal outcomes | Whole cohort (n=326)* | Gestational age at PPROM (weeks+days) | Unadjusted relative rate ratio of outcome for each additional week of gestation at PPROM (RR (95% CI), P value) |
|||
| 16+0-17+6 (n=82) | 18+0-19+6 (n=102) | 20+0-21+6 (n=105) | 22+0-22+6 (n=37) | |||
| Median (IQR) gestational age at birth (weeks+days) | 23+0 (20+2-27+4) | 19+2 (17+2-27+6) | 21+3 (19+4-27+4) | 23+1 (21+2-26+6) | 24+2 (22+6-28+1) | — |
| Live births: | ||||||
| No/total No (%) expectant management‡ | 98/223 (44) | 14/43 (33) | 27/70 (39) | 37/80 (46) | 20/30 (67) | 1.25 (1.08 to 1.45), 0.004 |
| Worst-best possible outcome (range) (minimum No/total No (%) to maximum No/total No (%)) § | 98/326 (30) to 201/326 (62) | 14/82 (17) to 53/82 (65) | 27/102 (26) to 59/102 (58) | 37/105 (35) to 62/105 (59) | 20/37 (54) to 27/37 (73) | |
| Median (IQR) gestational age at birth (weeks+days) | 28+2 (25+2-30+2) | 28+4 (27+6-34+2) | 28+4 (26+4-30+1) | 27+1 (23+4-30+4) | 26+3 (23+1-30+1) | |
| Survival to hospital discharge: | ||||||
| No/total No (%) total expectant management†‡ | 54/207 (26) | 7/40 (18) | 16/67 (24) | 21/74 (28) | 10/26 (38) | 1.19 (1.00 to 1.42), 0.06 |
| Worst-best possible outcome (range) (minimum No/total No (%) to maximum No/total No (%)) § | 54/326 (17) to 173/326 (53) | 7/82 (9) to 49/82 (60) | 16/102 (16) to 51/102 (50) | 21/105 (20) to 52/105 (50) | 10/37 (27) to 21/37 (57) | |
| Median (IQR) gestational age at birth (weeks+days) | 29+4 (27+1-34+2) | 34+2 (29+0-36+4) | 28+5 (27+2-33+6) | 30+2 (26+3-33+5) | 29+2 (27+6-31+1) | |
| Survival to hospital discharge without severe morbidity: | ||||||
| No/total No (%) expectant management†‡ | 38/207 (18) | 5/40 (13) | 11/67 (16) | 13/74 (18) | 9/26 (35) | 1.21 (0.99 to 1.48), 0.07 |
| Worst-best possible outcome (range) (minimum No/total No (%) to maximum No/total No (%)) § | 38/326 (12) to 157/326 (48) | 5/82 (6) to 51/82 (62) | 11/102 (11) to 46/102 (45) | 13/105 (12) to 44/105 (42) | 9/37 (24) to 20/37 (54) | |
| Median (IQR) gestational age at birth (weeks+days) | 30+2 (28+2-35+5) | 34+3 (34+2-36+4) | 28+5 (26+0-35+5) | 31+5 (28+4–35+5) | 30+1 (28+2-31+1) | |
CI=confidence interval; IQR=interquartile range; PPROM=preterm prelabour rupture of membranes; RR=relative rate.
*Gestational age at PPROM 16+0-22+6 weeks+days.
†Excludes pregnancies with babies that were live born at ≥22+0 weeks' gestational age with missing discharge status. PPROM: 16+0-17+6 (n=3), 18+0-19+6 (n=3), 20+0-21+6 (n=6), and 22+0-22+6 weeks’ gestation livebirth status (n=4).
‡Excludes pregnancies with termination for medical reasons.
§Includes pregnancies with termination for medical reasons and missing discharge status.