Figure 8.

Decreased Mfn2 expression and reduced MLC were observed in cardiac specimens from obese patients. A–H) BMI, TG, total cholesterol, EF, FS, E/A ratio, IVS and LAD are compared between obese patients (n = 13) and non‐obese individuals (n = 16) (Mean± SEM, *P<0.05, **P<0.01). I) mitochondria and LDs were co‐staining in the frozen human atrial tissue from obese or non‐obese individuals. n = 3 per group. J) Mfn2 protein expression in atrial tissue from non‐obese or obese individuals were determined by western‐blot, n = 3 per group. K) IP assay were performed in human atrial tissue to detect the binding of Mfn2 and Hsc70. L and M) Mfn2‐Hsc70 interaction, Mfn2 acetylation level and Mfn2 ubiquitylation level were determined in human atrial tissue from obese and non‐obese individuals.