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. Author manuscript; available in PMC: 2024 Apr 10.
Published in final edited form as: Ann Rheum Dis. 2022 Sep 15;82(2):262–271. doi: 10.1136/ard-2021-221269

Figure 5. Panobinostat effects on joint tissues in normal mice.

Figure 5.

(A). C57BL/6J mice (n=6) received intraperitoneal injections of Panobinostat on Day 0, day 2 and Day 4 and were euthanized 1–3 h after the last injection.

(B). C57BL/6J mice (n=8 each) received one intraperitoneal injection of vehicle and Panobinostat (2.5 mg/kg) and 2 h later IL-1β (50 ng in 10 μl of 5% dextrose) was injected into the right knee and 10 μl of 5% dextrose injected into the left knee. Six h after the IL-1β injection the mice were euthanized. Cartilage and synovium were resected for RNA isolation and RT-qPCR analysis. Data are shown as fold increase in response to IL-1β in Control animals and in Panobinostat treated animals.

***= p<0.001; **= p<0.01; *= p<0.05