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Chronic TNBS-Colitis induced in BALB/c mice. The chronic colitis is marked by three phases dominated by a Th1 response, a Th17 response and finally, a mixed Th17/IL-13 response. Each of these phases are characterized by a unique set of cytokines. Fibrosis occurs during phase three under the influence of IL-13 and TGF-β1.
