FIG. 1.
Map of HHV-8 LUR showing the locations of the conserved and unique ORFs, including sequences tested for transforming ability, and a schematic diagram of the ∼140-kb LUR sequence flanked by terminal repeats (TR). HHV-8 fragments tested in the focus-forming assay (17, 23, and 199) are shown as solid bars below the map. The locations of T0.7 and kaposin (K12) sequences within fragment 23 are indicated. The solid arrows indicate HHV-8 ORFs conserved in HVS, and the open arrows indicate the unique HHV-8 ORFs. Repeat regions are shown as small filled rectangles above the ORFs (frnk, vnct, waka/jwka, zppa, moi, and mdsk). KS330 and KS631 are the fragments of HHV-8 that were identified first. CBP, complement binding protein; ss DBP, single-stranded DNA binding protein; gB, glycoprotein B; DNA pol, DNA polymerase; DHFR, dihydrofolate reductase; TS, thymidylate synthetase; MIP, macrophage inflammatory protein; nut-1, nuclear transcript 1; Teg, tegument protein; TK, thymidine kinase; gH, glycoprotein H; MCP, major capsid protein; gM, glycoprotein M; UDG, uracil DNA glucosidase; gL, glycoprotein L; R-trans, transactivator; gX, glycoprotein X; vIRF, viral interferon regulatory factor; RRS, ribonucleotide reductase, small; RRL, ribonucleotide reductase, large; CycD, cyclin D homolog; Adh, immunoglobulin family adhesion protein; GCR, G-protein-coupled receptor. The map was adapted from Fig. 1 of reference 56 with the permission of the publisher.