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. Author manuscript; available in PMC: 2024 Apr 10.
Published in final edited form as: Glia. 2020 Feb 17;68(7):1513–1530. doi: 10.1002/glia.23799

FIGURE 9. Administration of an NOR antagonist results in sex-specific acceleration of rat brain myelination.

FIGURE 9.

(a) Experimental schedule of BAN-ORL 24 administration: 9-day-old female and male pups were administered the blood brain barrier permeable NOR antagonist BAN-ORL24 (1mg/kg/day, IP) or vehicle (controls). Animals were sacrificed at postnatal day 14, and the cerebral hemispheres analyzed for the expression of MBP, MAG and MOG, using β-actin levels as loading controls. The figure shows representative western blots for the female (b-c) and male (e-g) pups. Bar graphs are the mean ± SEM from a total of at least 9 pups/group/sex from 3 different litters. ****p<0.001, **p<0.006.