Table 2.
Performance of Different Versions of the Duke Clinical Criteria Among Different Groups
| Patient Group | Type of Calculation | Number of Patients n |
Duke-Li 2000 Criteria % 95% CI % |
Duke-ESC 2015 Criteria % 95% CI % |
Duke-ISCVID 2023 Criteria % 95% CI % |
|---|---|---|---|---|---|
| Confirmed IE patients | Sensitivitya | 443 | 70 (65–74) |
70 (65–74) |
84 (81–87) |
| Prosthetic valve | Sensitivitya | 113 | 66 (57–75) |
69 (60–77) |
84 (76–91) |
| Native valve | Sensitivitya | 312 | 74 (57–75) |
73 (68–78) |
88 (84–92) |
| Rejected IE cases | Specificityb | 731 | 74 (70–76) |
74 (71–77) |
60 (56–63) |
Abbreviations: CI, confidence interval; ESC, European Society for Cardiology; IE, infective endocarditis; ISCVID, International Society of Cardiovascular Infectious Diseases.
aDefinite IE cases by Duke clinical criteria being diagnosed as IE by the Endocarditis Team.
bRejected cases by Duke clinical criteria being diagnosed as non-IE by the Endocarditis Team.