Table 1. Characteristics of native glutamate transporters and their water-soluble QTY variants.
| Name | RMSD | pI | MW (KD) | TM variation (%) | Overall variation (%) |
|---|---|---|---|---|---|
| EAA1 - | 8.52 | 59.6 | - | - | |
| EAA1QTY | 0.717Å | 8.44 | 59.9 | 53.88 | 17.89 |
| EAA2 - | 6.09 | 62.1 | - | - | |
| EAA2QTY | 0.948Å | 6.09 | 62.4 | 48.92 | 15.85 |
| EAA3 - | 5.56 | 57.1 | - | - | |
| EAA3QTY | 0.905Å | 5.56 | 57.4 | 50.27 | 17.74 |
| EAA4 - | 9.26 | 61.5 | - | - | |
| EAA4QTY | 0.796Å | 9.07 | 61.9 | 48.92 | 16.13 |
| VGLUT1 - | 7.2 | 61.6 | - | - | |
| VGLUT1QTY | 1.604Å | 7.19 | 62 | 43.93 | 13.57 |
| VGLUT2 - | 6.62 | 64.3 | - | - | |
| VGLUT2QTY | 0.971Å | 6.61 | 64.7 | 42.1 | 12.37 |
| VGLUT3 - | 5.95 | 64.9 | - | - | |
| VGLUT3QTY | 1.422Å | 5.95 | 65.3 | 41.11 | 12.56 |
| YLAT2 - | 5.62 | 56.8 | - | - | |
| YLAT2QTY | 0.528Å | 5.62 | 57.5 | 49.6 | 24.27 |
Residue mean-square distance (RMSD) in Å, Isoelectric focusing (pI), Molecular weight (MW), Transmembrane (TM),— = not applicable. The internal and external loops have no changes, the overall changes are significant, and the TM changes are rather large.