a, The graph AN is composed of two large chunks ABd and AdB that are connected by a single edge. The chunk AdB is a Fan graph with f nodes. The chunk ABd is a fan-like graph with a vertices in a central hub and b blades of two nodes each. The total population size is N = a + 2b + f (here a = b = 5, f = 11, and N = 26). The edge weights are defined such that different circled units within the chunks interact only rarely, and the chunks themselves interact even more rarely. b, Here we consider graph AN with population size N = 1001 and (a, b, f) = (30, 85, 801). The fixation probabilities under Bd- and dB-updating are computed by numerically solving the underlying Markov chain. We find that the inequality is satisfied for r ∈ (1, 1.09) and the inequality is satisfied for r ∈ (1, 1.2). In particular, at r = 1.05 the ratios satisfy and .