Figure 2.

Analysis of sc-seq data for early disease detection. (A) The sc-seq data obtained from a brain biopsy can be visualized in the form of a UMAP embedding, where each cell is represented by a dot. Cells (dots) with similar phenotype (transcriptome or epigenetic marks) cluster together, which are assigned to cell types based on prior knowledge. (B) Clusters in A might contain cells undergoing transition, such as differentiation or cell cycles, which can be visualized by means of trajectory analysis. Here, cells that deviate from established healthy trajectories may aid in early disease detection. Based on [10] and [2]. Note – synthesized data.