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. Author manuscript; available in PMC: 2024 Apr 10.
Published in final edited form as: Chem Commun (Camb). 2023 Oct 17;59(83):12499–12502. doi: 10.1039/d3cc04402e

Scheme 1. The SWAMNA platform for analyzing DNA and RNA modifications.

Scheme 1.

Cellular DNA and RNA were extracted and purified, then enzymatically digested into mononucleosides using a “one-pot” approach. The resulting digested nucleosides underwent purification through PGC solid-phase extraction and were subsequently subjected to derivatization using permethylation. The zenoSWATH was employed for the analysis, and the NuMo Finder search engine was developed to identify and quantify the modifications present.