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. 2024 Mar 11;16(6):5336–5353. doi: 10.18632/aging.205651

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Copyright: © 2024 Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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mir-31-5p antagomir restored intestinal mucosal tight junction protein and reduced colonic inflammation in DSS-induced colitis mice. (A) Immunofluorescence staining of ZO-1 and occludin in colon tissue (x200 magnification). (B) Quantitative fluorescence analysis of ZO-1 and occludin (ordinate represented the average fluorescence intensity analyzed by ImageJ software). (C) ELISA analysis of the expression of IL-1β, TNF-α, TGF-β and IL-10 in colon. Each bar represents mean ± SD, n ≥ 3 from each group. ns represented P > 0.05, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001 vs. DSS group.