Table 1 . Changes in the oral treatment of ADPKD in the CKD without KRT.
| Variables, n (%) | Year | P-value | ||||||
|---|---|---|---|---|---|---|---|---|
| 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | ||
| Overall ADPKD cases in the CKD without KRT (3062 data points) | 412 (100) | 448 (100) | 478 (100) | 494 (100) | 470 (100) | 423 (100) | 337 (100) | |
| Diuretics | 97 (24) | 102 (23) | 141 (29) | 152 (31) | 151 (32) | 150 (35) | 143 (42) | <0.0001 |
| Tolvaptan (>15 mg/day) | 8 (1.9) | 21 (4.7) | 54 (11) | 66 (13) | 78 (17) | 85 (20) | 83 (25) | <0.0001 |
| Tolvaptan (≤15 mg/day) | 5 (1.2) | 7 (1.6) | 13 (2.7) | 17 (3.4) | 17 (3.6) | 15 (3.5) | 18 (5.3) | 0.0002 |
| Loop | 62 (15) | 64 (14) | 67 (14) | 60 (12) | 47 (10) | 42 (10) | 39 (12) | 0.005 |
| Thiazide | 30 (7.3) | 27 (6) | 34 (7.1) | 30 (6.1) | 31 (6.6) | 22 (5.2) | 24 (7.1) | 0.63 |
| Anti-aldosterone | 18 (4.4) | 18 (4.0) | 21 (4.4) | 23 (4.7) | 17 (3.6) | 16 (3.8) | 13 (3.9) | 0.59 |
| Antihypertensives | 267 (65) | 265 (59) | 284 (59) | 297 (60) | 298 (63) | 265 (63) | 227 (67) | 0.17 |
| ARB | 193 (47) | 191 (43) | 194 (41) | 190 (38) | 196 (42) | 175 (41) | 149 (44) | 0.41 |
| ACEI | 22 (5.3) | 22 (4.9) | 27 (5.6) | 32 (6.5) | 21 (4.5) | 20 (4.7) | 14 (4.2) | 0.41 |
| Renin blocker | 2 (0.49) | 5 (1.1) | 3 (0.63) | 2 (0.40) | 3 (0.64) | 2 (0.47) | 2 (0.59) | 0.61 |
| CCB | 190 (46) | 182 (41) | 185 (39) | 206 (42) | 199 (42) | 176 (42) | 147 (44) | 0.15 |
| β-blocker | 55 (13) | 54 (12) | 52 (11) | 72 (15) | 69 (15) | 59 (14) | 48 (14) | 0.22 |
| Other | 51 (12) | 48 (11) | 36 (7.5) | 39 (7.9) | 42 (8.9) | 39 (9.2) | 41 (12) | 0.64 |
| Lipid-lowering drug | 91 (22) | 96 (21) | 113 (24) | 114 (23) | 100 (21) | 93 (22) | 77 (23) | 0.96 |
| Statin | 79 (19) | 86 (19) | 105 (22) | 108 (22) | 95 (20) | 88 (21) | 73 (22) | 0.42 |
| Fibrate | 4 (1.0) | 1 (0.22) | 3 (0.63) | 3 (0.60) | 3 (0.64) | 3 (0.71) | 3 (0.89) | 0.74 |
| Other | 10 (2.4) | 11 (2.5) | 7 (1.5) | 8 (1.6) | 7 (1.5) | 5 (1.2) | 5 (1.5) | 0.11 |
Abbreviations: ADPKD, Autosomal Dominant Polycystic Kidney Disease; CKD, Chronic Kidney Disease; KRT, Kidney Replacement Therapy; ARB, Angiotensin II Receptor Blocker; ACEI, Angiotensin-Converting Enzyme Inhibitor; CCB, Calcium Channel Blocker