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. 2024 Mar 20;628(8007):424–432. doi: 10.1038/s41586-024-07182-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Size of the Fn pangenome split by the core genome (≥95%) (black) and accessory (<95%) genome (grey). n = 10,000 random subsamplings of 135 Fn genomes. Data is plotted as median ± s.d. b, Size of the Fn pangenome split by CRC-associated (orange) and oral-associated (blue) niche origin, with respective core and accessory genomes labeled. n = 10,000 random subsamplings of 55 Fn CRC-associated and 80 Fn oral-associated genomes. Data is plotted as median ± s.d. c, Size of the Fn pangenome split by Fn subspecies, Fna (red), Fnn (gold), Fnp (purple), Fnv (brown), with respective core and accessory genomes labeled. n = 10,000 random subsamplings of 75 Fna, 17 Fnn, 33 Fnp, and 10 Fnv genomes. Data is plotted as median ± s.d. d-e, Maximum-likelihood dendrograms of d, fadA and e, fplA nucleotide and amino acid sequences. For each genome, tree end points indicate Fn subspecies; Fna (red), Fnn (gold), Fnp (purple), Fnv (brown). f, Column graph depicts the proportion of Fn genomes containing canonical Fn virulence factors, subset by Fna (red), non-Fna (black) subspecies. Statistical analysis performed using two sample Z test, two-tailed. NS, not significant.