Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 20;628(8007):424–432. doi: 10.1038/s41586-024-07182-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 4 — a, Bar plots demonstrate the proportion of stool metagenomic samples from patients with CRC or healthy controls in which putative eut and pdu operons were detected. Statistical analysis performed using two sample Z test, two-tailed. Cohort sample sizes are indicated at the bottom of each panel. b-c, Differentially expressed genes (with log2-transformed fold change ≥ 0.58 and ≤ −0.58 with -log10(p-value) ≥ 1.30) of a representative Fna C1 strain (KCOM 3764) and a representative Fna C2 strain (SB010) under (b) ethanolamine (EA) or (c) 1,2-propanediol (1,2-PD) exposure as compared to their respective unexposed controls. Top five significant (-log10(p-value) ≥ 1.30) upregulated and downregulated genes are labeled. d, Differentally expressed genes (with log2-transformed fold change ≥ 0.58 and ≤ −0.58 with -log10(p-value) ≥ 1.30) in SB010 under Vitamin B12 exposure alone as compared to unexposed control. All differentially expressed genes labeled. For b-d, vertical dotted lines indicate the threshold of significant gene expression, defined as log2-transformed fold change ≥ 0.58 and ≤ −0.58. Statistical analysis performed using glmQLFTest, 2-sided. Data point colors indicate whether a gene is categorized as part of the Fna core genome (red), Fna C1-associated accessory genome (green), or Fna C2-associated accessory genome (lavender) by PPanGGOLiN.