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The severity of histological alterations in cortical tissues of histopathological alterations in OVX/D-Gal rats treated with E. bonariensis extract
| Histopathological damage | SO | OVX/D-Gal | Donepezil | E. bonariensis (mg/kg) | ||
|---|---|---|---|---|---|---|
| 50 | 100 | 200 | ||||
| Degeneration | − | + + + | + | + + | + | + + |
| Perineuronal vacuolation | − | + + + | − | + + | + | + + |
| Apoptosis | − | + + + | − | + + | + | + |
| Pyknotic nuclei | − | + + | + | + + | + | + + |
− Absent
+ Mild
+ + Moderate
+ + + Severe
