Fig. 2.

Effect of DMF and RUT treatments on neurobehavioral changes. a Rotarod test, b Actophotometer test, and c String test for grip strength. Open field test: d immobility time, e rearing, and f ambulation frequency. Data represent mean ± SEM (n = 6). ** p  < 0.01 vs. NC, ^## p  < 0.01 vs. CPZ group, ^{^} p  < 0.05 vs. CPZ + DMF, and ^•• p  < 0.01 vs. CPZ + RUT50 (ANOVA). NC: control group fed on normal diet; CPZ: cuprizone group fed on diet enriched with 0.2% (w/w) cuprizone; DMF: dimethyl fumarate 15 mg/kg; RUT50: rutin 50 mg/kg; RUT100: rutin 100 mg/kg