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. 2024 Mar 21;32(2):1295–1315. doi: 10.1007/s10787-024-01442-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Electron micrographs of the CC of the CPZ-fed group showing stages of phagocytosis of myelin debris by microglia. Many distracted OLs were seen close to unhealthy nerve fibers. a Injured myelin ( ) and destructed OLs ( ) appear close to this injured myelin. b Microglia spread their processes ( →) among these axons. c–e Phagosomes with many debris ( ). f Therefore, excessive demyelination and the accompanying phagocytosis might lead to numerous gaps and empty areas just next to microglia ( ). ( n = 3 per group). CPZ; cuprizone, CC corpus callosum; OLs: oligodendrocytes

Inline graphic — Electron micrographs of the CC of the CPZ-fed group showing stages of phagocytosis of myelin debris by microglia. Many distracted OLs were seen close to unhealthy nerve fibers. a Injured myelin ( ) and destructed OLs ( ) appear close to this injured myelin. b Microglia spread their processes ( →) among these axons. c–e Phagosomes with many debris ( ). f Therefore, excessive demyelination and the accompanying phagocytosis might lead to numerous gaps and empty areas just next to microglia ( ). ( n = 3 per group). CPZ; cuprizone, CC corpus callosum; OLs: oligodendrocytes