Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 21;32(2):1295–1315. doi: 10.1007/s10787-024-01442-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Myelination in different treatment protocols. In the DMF group (a, d), remyelination was demonstrated in many nerve fibers. However, in RUT50 (b, e), the myelinated axons were less than those in the DMF group. In RUT100 (c, f), the myelinated axons were more abundant, with a thicker myelin sheath, than both RUT50 and DMF. Oligodendrocyte cells ( ) were demonstrated frequently in the RUT100 group. g The percentage of myelinated fibers in the CC in TEM sections. h Quantification of the G ratio in the CC. Values are expressed as the mean ± SEM. * p < 0.05, ** p < 0.01 vs. NC group, ^# p < 0.05, ^## p < 0.01 vs. CPZ group, ^{^^} p < 0.01 vs. CPZ + DMF, and ^• p < 0.05, ^•• p < 0.01 vs. CPZ + RUT50 (ANOVA). NC: control group fed on normal diet; CPZ: cuprizone group fed on diet enriched with 0.2% (w/w) cuprizone; DMF: dimethyl fumarate 15 mg/kg; RUT50: rutin 50 mg/kg; RUT100: rutin 100 mg/kg; CC: corpus callosum

Inline graphic — Myelination in different treatment protocols. In the DMF group (a, d), remyelination was demonstrated in many nerve fibers. However, in RUT50 (b, e), the myelinated axons were less than those in the DMF group. In RUT100 (c, f), the myelinated axons were more abundant, with a thicker myelin sheath, than both RUT50 and DMF. Oligodendrocyte cells ( ) were demonstrated frequently in the RUT100 group. g The percentage of myelinated fibers in the CC in TEM sections. h Quantification of the G ratio in the CC. Values are expressed as the mean ± SEM. * p < 0.05, ** p < 0.01 vs. NC group, ^# p < 0.05, ^## p < 0.01 vs. CPZ group, ^{^^} p < 0.01 vs. CPZ + DMF, and ^• p < 0.05, ^•• p < 0.01 vs. CPZ + RUT50 (ANOVA). NC: control group fed on normal diet; CPZ: cuprizone group fed on diet enriched with 0.2% (w/w) cuprizone; DMF: dimethyl fumarate 15 mg/kg; RUT50: rutin 50 mg/kg; RUT100: rutin 100 mg/kg; CC: corpus callosum