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Effect of treatment protocols on Nrf2 expression. Data represent mean ± SEM. ** p < 0.01 vs. NC group, ## p < 0.01 vs. CPZ group, ^^ p < 0.01 vs. CPZ + DMF, and.• p < 0.05 vs. CPZ + RUT50 (ANOVA). NC: control group fed on normal diet; CPZ: cuprizone group fed on diet enriched with 0.2% (w/w) cuprizone; DMF: dimethyl fumarate 15 mg/kg; RUT50: rutin 50 mg/kg; RUT100: rutin 100 mg/kg; Nrf2: the transcription factor (erythroid-derived) nuclear factor-like 2
