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. 2024 Apr 10;14:8417. doi: 10.1038/s41598-024-58888-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed m6A genes in IVDD and their immunological characteristics. (A) Results of GSEA analysis of control samples in the training set. (B) Results of GSEA analysis of IVDD samples in the training set. (C) Boxplot of m6A gene expression comparison between Normal and IVDD groups. (D) Heat map of five m6A differentially expressed genes in Normal and IVDD groups. Red represents high expression and blue represents low expression. (E) Content of 22 immune cell species in patients in Normal versus IVDD groups. (F) Differences in the content of 22 immune cells in patients in the Normal versus IVDD groups. *P < 0.05, **P < 0.01, ***P < 0.001. (G) Barplot shows KEGG pathway enrichment results of m6A differentially expressed genes in IVDD.