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. 2024 Feb 13;115(4):1283–1295. doi: 10.1111/cas.16104

FIGURE 1.

FIGURE 1

Frequency and concordance of KRAS mutation in tumor DNA and circulating tumor DNA (ctDNA). (A) Scheme of KRAS mutation frequency in multiplex and single droplet digital PCR (ddPCR) in 128 patients with pancreatic ductal adenocarcinoma (PDAC). (B) Concordance of KRAS mutation between tumor DNA and ctDNA in 69 patients. Heatmap indicating mutations detected in both tumor DNA and ctDNA (green), only tumor DNA (orange), and only ctDNA (yellow). (C) Comparison of frequencies of KRAS mutation detected in plasma and tumor DNA. A single KRAS mutation for each G12D, G12V, G12C, and G12R or seven common mutations (multiplex) for G12A, G12C, G12D, G12R, G12S, G12V, and G13D were detected using ddPCR. D, detected; ND, not detected.