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. 2024 Feb 13;115(4):1283–1295. doi: 10.1111/cas.16104

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© 2024 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Kaplan–Meier curves of progression‐free survival (PFS) and overall survival (OS) based on KRAS G12C detected in tumor DNA and circulating tumor DNA (ctDNA). (A) In tumor DNA, the difference in survival between the KRAS G12C‐detected group, the other hotspot (KRAS G12D/G12V/G12R)‐detected group, and the nondetected group was analyzed. There was no difference between the groups in tumor DNA. (B) In ctDNA, the KRAS G12C‐detected group showed significantly lower survival rates than the nondetected group.