FIGURE 2.

Phenobarbital robustly dysregulates the hippocampal transcriptome, while levetiracetam does not. (A) Volcano plot showing differential expression (PB vs. VEH). PB exposure resulted in 8- upregulated and 44 downregulated transcripts. FDR cutoff = 0.05, Fold change cutoff: -1.25 to 1.25. (B) Volcano plot showing differential expression (LEV vs. VEH). LEV exposure upregulated 6 transcripts and downregulated 9 transcripts. The top 10 up and downregulated genes for PHB and LEV are shown in Tables 1, 2. Full lists of transcripts are shown in Supplementary Table S2; differentially expressed transcripts following PB treatment are shown in Supplementary Table S3; differentially expressed transcripts following LEV treatment are shown in Supplementary Table S4. (C) Heatmap showing similar expression patterns between VEH and LEV, which differs from the pattern observed with PB.