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. 2024 Apr 10;25(3):bbae151. doi: 10.1093/bib/bbae151

Figure 3.

Figure 3

The prognostic significance of HLA-I indicators in breast cancer. (A) Univariate Cox proportional hazard models for RFS in the whole breast cancer cohort and different clinical subtypes. (B) Kaplan–Meier survival curve according to HLA-A/B/C mean mRNA expression groups for RFS in whole breast cancer cohort. (C–D) Kaplan–Meier survival curve according to HLA-I LOH groups (C) and Pr groups (D) for RFS in TNBCs. (E) Kaplan–Meier survival curve according to HLA-A/B/C mean mRNA expression groups for RFS in whole breast cancer patients fully heterozygous at HLA-I loci. (F–G) Kaplan–Meier survival curve according to HLA-I LOH groups (F) and Pr groups (G) for RFS in TNBCs fully heterozygous at HLA-I loci. Abbreviations: RFS, relapse-free survival; LOH, loss of heterozygosity; HED, evolutionary divergence of HLA class I genotype; Pr, promiscuity. See also Supplementary Figure 3.