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Hopping transitions along the phase boundary. (A) Free-energy profiles F(R) along the phase boundary (Tm, fm) (see Fig. 2). The barrier separating NBA and UBA increases at low Tm and high fm values. (B) Time traces of R obtained by using Brownian dynamics simulations. The values of T and f are 305 K and 6 pN, respectively. The arrows (black, red, and green) indicate the residence times in the NBA for three trajectories.
