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. 2005 Apr 29;102(19):6954–6959. doi: 10.1073/pnas.0408518102

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Fig. 3. — Tubular cell apoptosis. (A) The number of TUNEL-positive cells (blue staining) per tubule in noncystic tubules in the cortex was increased in vehicle-treated Cy/+ rats compared with vehicle-treated +/+ rats. IDN-8050-treated Cy/+ rats had significantly fewer TUNEL-positive cells per tubule compared with vehicle-treated Cy/+ rats. *, P = 0.05 vs. +/+; **, P < 0.05 vs. vehicle-treated Cy/+, not significant vs. +/+.(B) Vehicle-treated +/+ rats had no TUNEL-positive cells per tubule compared with (C) vehicle-treated Cy/+ rats (arrows). (D) IDN-8050 decreased the number of TUNEL-positive cells per tubule in Cy/+ rats. (E) The number of TUNEL-positive cells in tubular epithelial cells lining the cysts was significantly decreased by IDN-8050. *, P = 0.02 vs. vehicle-treated Cy/+.(F and G) Representative picture of the TUNEL staining (arrows) in cysts of vehicle-treated Cy/+ (F) and IDN-8050-treated Cy/+ (G) rats.