Table 1. Effect of IDN-8050 in PKD.

Mice	Body weight, g	2K/TBW, %	CVD, %	BUN, mg/dl
+/+	267 ± 13	0.9 ± 0.04	0.4 ± 0.1	23 ± 1
	n = 8	n = 8	n = 4	n = 4
+/+ IDN-8050	249 ± 28	0.8 ± 0.02	0.5 ± 0.2	19 ± 2
	n = 4	n = 3	n = 3	n = 3
Cy/+	259 ± 7	2.1 ± 0.1*	43 ± 2*	38 ± 1*
	n = 7	n = 8	n = 8	n = 7
Cy/+ IDN-8050	257 ± 17	1.6 ± 0.1**	30 ± 3**	26 ± 1**
	n = 7	n = 6	n = 6	n = 3

CVD, cyst volume density. *, P < 0.001 vs. +/+ mice; **, P < 0.001 vs. Cy/+ mice. The P value for the interaction between IDN-8050 and genotype was 0.04 for 2K/TBW (%), 0.03 for CVD, and 0.02 for BUN.