Table 1. Maximal relaxations to CPA as a percent of PE-induced tone (Rmax) and concentrations of CPA causing half-maximal relaxation (EC50) under different experimental conditions.
| Group (n) | Rmax, % | EC50, μM |
|---|---|---|
| Control (8) | 95.1 ± 4.7 | 13.2 (10.7-16.3) |
| 5-MTHF (4) | 94.2 ± 6.6 | 11.2 (8.5-14.6) |
| APB (8) | 23.5 ± 1.9 | 24.1 (17.7-32.7) |
| 5-MTHF plus APB (12) | 81.0 ± 5.8 | 19.3 (14.5-25.6) |
| FA plus APB (6) | 22.1 ± 2.3 | 20.2 (13.4-30.4) |
| Methotrexate plus APB (6) | 31.9 ± 6.3 | 23.2 (11.5-46.7) |
| Control (9) | 90.7 ± 2.0 | 17.6 (15.3-20.1) |
| (6R)-BH4 (3) | 91.9 ± 8.9 | 12.7 (5.5-29.3) |
| APB (9) | 28.8 ± 3.4 | 21.7 (13.7-34.3) |
| (6R)-BH4 plus APB (5) | 79.1 ± 7.4 | 14.4 (5.2-40.0) |
| BH2 plus APB (4) | 30.0 ± 4.2 | 26.9 (17.9-40.3) |
| Control (7) | 91.5 ± 6.3 | 12.5 (9.3-16.6) |
| Catalase (4) | 99.6 ± 3.9 | 8.8 (7.4-10.5) |
| APB (7) | 30.4 ± 3.8 | 16.8 (8.7-32.4) |
| Catalase plus APB (4) | 86.5 ± 3.4 | 13.9 (9.7-19.8) |