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Superposition of the binding regions of BIV TAR complexed to the JDV ARM (green) and HIV-1 TAR complexed to argininamide (gray). Bases important for the binding of ARM peptides to BIV TAR (thick bases) (26) were used to overlap the JDV complex with an NMR model of the HIV-1 TAR complex (19). In the JDV complex, Tyr-81 (blue) stacks on the U10 bulge base of BIV TAR, positioning it to hydrogen bond to the A13:U24 base pair and form the base triple.
