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. Author manuscript; available in PMC: 2024 Apr 11.
Published in final edited form as: Glia. 2023 Jun 7;71(9):2285–2303. doi: 10.1002/glia.24423

FIGURE 4. No change in extent of myelination in the dorsal column of the cervical spinal cord following adultonset sulfatide depletion.

FIGURE 4.

Quantitative analysis of the dorsal column of the spinal cord revealed no difference in the percent of myelinated versus unmyelinated axon (a), or myelin thickness as calculated by g ratios (b). Similar to the corpus callosum, quantitative analysis of the combined axonal and myelin pathologies revealed a significant increase in the CST-cKO mice at PI 11-months but not at 3- and 6-months PI (c). However, when the individual pathologies were compared, myelin pathologies were comparable between genotypes (d-f) while axonal degeneration was significantly more abundant in the CST-cKO at 11-months PI compared to 11-months PI CTL mice (g). All data were statistically compared using a 2-way ANOVA; ** p < .005 ****p < .0001.