Table 1. IMO sequences, chemical modifications, and mass spectral analysis data.
Mol. wt.
|
|||
---|---|---|---|
Number | Sequence* | Found | Calcd |
CpG oligomer 1 | 5′-TCGTCGTTTGTCGTTTGTCGTT-3′ | 7,054.8 | 7,056.4 |
IMO 2 | 5′-TCTGTCRTTCT-X-TCTTRCTGTCT-5′ | 7,146.2 | 7,145.8 |
IMO 3 | 5′-TCRTCRTTCTG-X-GTCTTRCTRCT-5′ | 7,194.8 | 7,193.9 |
IMO 4 | 5′-TCRAACRTTCR-X-RCTT RCAARCT-5′ | 7,225.2 | 7,227.9 |
Control IMO 5 | 5′-TCTCACCTTCT-X-TCTTCCACTCT-5′ | 6,996.3 | 7,005.7 |
Control IMO 6 | 5′-TRCTRCTTCTG-X-GTCTTCRTCRT-5′ | 7,192.3 | 7,193.9 |
Mol. wt., molecular weight; Calcd, theoretically calculated values.
All oligonucleotides are phosphorthioate backbone modified. CG and CR dinucleotides are underlined; R and X stand for 2′-deoxy-7-deazaguanosine and glycerol linker, respectively.