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Effect of down-regulation of STAT3 expression on SHP-1 gene silencing. (A) Promoter methylation status in the 2A cells treated with nonsense (NS) siRNA (Upper) and STAT3-specific siRNA (Lower). (B) Protein expression of STAT3, SHP-1, and the control proteins. (C) Association of the STAT3/DNMT1/HDAC1 complex with the SHP-1 promoter after 72 h of cell treatment medium alone (–), STAT3 siRNA, or DNMT1 AS-ON(1) detected in the ChIP assay.
