Table 1.
Behavioral testing results
| Condition | Genotype | n | Cohort | OP novelty preference (%) |
OR novelty preference (%) |
|---|---|---|---|---|---|
| IL-6 WT | IL-6 + / + MRL/lpr | 14–15 | A + B | 45.4 ± 2.3 | 48.9 ± 4.3 |
| IL-6 KO | IL-6 -/- MRL/lpr | 14–15 | A + B | 60.2 ± 2.3 | 67.9 ± 3.6 |
| p-value | – | – | 9.7 × 10–5**** | 0.002** |
| Condition | Behavioral spectrometer (% activity) |
PS immobility (%) |
Open field time in center (% of total) |
EPM open arm (seconds) | SP (%) |
|---|---|---|---|---|---|
| IL-6 WT | 72.7 ± 0.7 | 45.0 ± 2.5 | 15.5 ± 1.7 | 138.3 ± 16.3 | 53.1 ± 2.3 |
| IL-6 KO | 73.2 ± 0.8 | 53.4 ± 3.3 | 18 ± 2.3 | 134.4 ± 11.4 | 54 ± 2.1 |
| p-value | 0.647 | 0.054 | 0.380 | 0.436 | 0.783 |
IL-6 KO vs IL-6 WT scores in behavioral testing. Means ± standard errors are provided for each outcome measured. Within-genotype outcomes were statistically equivalent between cohort A and B
OP, object placement; OR, object recognition; PS, Porsolt swim; EPM, elevated plus maze; SP, social preference
Bold p-values are significant. **p < 0.01, ****p < 0.0001