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. 2024 Apr 10;24:205. doi: 10.1186/s12872-024-03877-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A Study Diagram: Cross-sectional Study to determine the prevalence of cardiac pathology in consecutively recruited participants with PTB in Lusaka, Zambia. 250 consecutively recruited participants with PTB will be matched to comparator participants without PTB on a 2:1 basis. Participants and comparators will undergo a comprehensive clinical assessment; functional assessments including Bandim TB score, WHO Performance status and six-minute walk test; point-of-care echocardiography; and 2D-echocardiography. B Study Diagram: Natural history study where participants with PTB will be followed up at 2- and 6-months to a) evaluate TB outcomes and b) determine change in functional status over time and c) biomarkers of inflammation and cardiac pathology in those with PTB with and without echocardiographic evidence of cardiac pathology at diagnosis. Legend: 6MWT = 6-min walk test