Table 2.
Comparison of multifocal GG/L nodules and second primary lung cancer
| Patient characteristics | Multifocal GG/L nodules (n = 139) | Second primary lung cancer (n = 63) | P value** | |
|---|---|---|---|---|
| Age | 0.361 | |||
| < 60 | 61 (43.9%) | 32 (50.8%) | ||
| ≥ 60 | 78 (56.1%) | 31 (49.2%) | ||
| BMI | 0.114 | |||
| ≤ 24.9 | 87 (62.6%) | 32 (50.8%) | ||
| > 24.9 | 52 (37.4%) | 31 (49.2%) | ||
| Sex | 0.002 | |||
| Male | 51 (36.7%) | 38 (60.3%) | ||
| Female | 88 (63.3%) | 25 (39.7%) | ||
| Smoking history | 0.000 | |||
| Yes | 40 (28.8%) | 35 (55.6%) | ||
| No | 99 (71.2%) | 28 (44.4%) | ||
| Drinking history | 0.404 | |||
| Yes | 24 (17.3%) | 14 (22.2%) | ||
| No | 115 (82.7%) | 49 (77.8%) | ||
| Personal history of neoplasia | 0.370 | |||
| Yes | 12 (8.6%) | 8 (12.7%) | ||
| No | 127 (91.4%) | 55 (87.3%) | ||
| Family history of neoplasia | 0.462 | |||
| Yes | 40 (28.8%) | 15 (23.8%) | ||
| No | 99 (71.2%) | 48 (76.2%) | ||
| Family history of lung cancer | 0.346 | |||
| Yes | 25 (18.0%) | 8 (12.7%) | ||
| No | 114 (82.0%) | 55 (87.3%) | ||
| Past medical history | 0.785 | |||
| Yes | 48 (34.5%) | 23 (36.5%) | ||
| No | 91 (65.5%) | 40 (63.5%) | ||
| Presenting symptoms before the first surgery | 0.022 | |||
| Yes | 47 (33.8%) | 32 (50.8%) | ||
| No | 92 (66.2%) | 31 (49.2%) | ||
| Number of resected tumors, n (%) | 0.224 | |||
| 2 | 104 (74.8%) | 56 (88.9%) | ||
| 3 | 26 (18.7%) | 6 (9.5%) | ||
| 4 | 6 (4.3%) | 1 (1.6%) | ||
| 5 | 2 (1.4%) | 0 (0.0%) | ||
| 6 | 1 (0.7%) | 0 (0.0%) | ||
| Times the patient underwent surgery, n (%) | 0.043 | |||
| 1 | 83 (59.7%) | 28 (44.4%) | ||
| 2 | 56 (40.3%) | 35 (55.6%) | ||
| Types of multiple cancers (simultaneous/metachronous) | 0.000 | |||
| Simultaneous lung cancers | 129 (92.8%) | 46 (73.0%) | ||
| Metachronous lung cancers | 10 (7.2%) | 17 (27.0%) | ||
| Types of surgery (thoracotomy/VATS) | 0.000 | |||
| VATS | 73 (52.5%) | 15 (23.8%) | ||
| Thoracotomy | 52 (37.4%) | 32 (50.8%) | ||
| Thoracotomy and VATS | 14 (10.1%) | 16 (25.4%) | ||
| Type(s) of resection of multiple lesions | 0.023 | |||
| Lobectomy + sublobar resection | 75 (54.0%) | 29 (46.0%) | ||
| Lobectomy + lobectomy | 21 (15.1%) | 17 (27.0%) | ||
| Sublobar resection + sublobar resection | 28 (20.1%) | 7 (11.1%) | ||
| Lobectomy | 14 (10.1%) | 6 (9.5%) | ||
| Pneumonectomy | 1 (0.7%) | 4 (6.3%) | ||
| Relationship of the locations of multiple lesions | 0.213 | |||
| Ipsilateral tumors | 90 (64.7%) | 35 (55.6%) | ||
| Bilateral tumors | 49 (35.3%) | 28 (44.4%) | ||
| With lung nodules not resected* | 0.014 | |||
| Yes | 34 (24.5%) | 6 (9.5%) | ||
| No | 105 (75.5%) | 57 (90.5%) | ||
| The highest stage tumor | 0.000 | |||
| I | 116 (83.5%) | 35 (55.6%) | ||
| II | 7 (5.0%) | 12 (19.0%) | ||
| III | 16 (11.5%) | 16 (25.4%) | ||
*With lung nodules not resected: the number of patients with unresected nodules in the lungs. **P values of less than 0.05 were considered statistically significant.