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. 2024 Mar 4;119(2):261–275. doi: 10.1007/s00395-024-01035-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Role of CD4⁺ T-cells in splenic and bone marrow myelopoiesis. Quantification of HSCs, GMPs/CMPs, and monocytes in the spleens a and bone marrow b of WT and CD4 knockout mice (CD4KO) 5 days after MI. c Quantification of proliferative activity of HSCs and GMPs/CMPs isolated from CD4KO BM after coculture with splenic Tregs or Tconv from WT mice. HSC haematopoietic stem cell, GMP granulocyte–macrophage progenitor, CMP common myeloid progenitor. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 (t-test)