Table 1.
The LINE-1 DNA Methylation Results (Comparisons by Groups).
| Group | Age, Years (Mean ± SD) | LINE-1 Methylation % Median (IQR) | ||||
|---|---|---|---|---|---|---|
| Case or Control Groups | APOE 3/4 Genotype Carriers | APOE 3/3 Genotype Carriers | Males | Females | ||
| AD | 77.4 ± 6.5 | 76.2 (69.8-81.9) | 75.80 (69.8-81.9) | 77.15 (69.6-80.9) | 80.75 (72.5-86.5) | 75.80 (69.1-78.6) |
| CTL | 74.9 ± 6 | 79.80 (73.2-83.8) | 83.75 (79.6-86.6) | 79.35 (70.1-83.1) | 78.68 (76.1-83.8) | 79.6 (71.4-83.6) |
| AD vs CTL, P value | .17 | .30 | .09 | .71 | .90 | .30 |
Abbreviations: AD, Alzheimer’s disease; APOE, apolipoprotein E; CTL, control group participants; IQR, interquartile range; LINE-1, long interspersed nuclear element 1; SD, standard deviation.