Figure 2.

Deletion of Cbfβ in articular cartilage resulted in an OA-like phenotype with decreased Aggrecan and Col2α1 expression in vivo. (A) H&E staining and (B) Safranin O staining of the knee joint from TMX or vehicle induction in 4.5-month-old male Cbfβ^f/fAggrecan-CreER^T mice. Blue and green arrows show irregular knee joint surface in TMX-induced Cbfβ^f/fAggrecan-CreER^T mice. (C) Knee joint Osteoarthritis Research Society International (OARSI) score of B, n=3. (D, E) IF staining of Aggrecan and Col2α1 in knee joint from 4.5-month-old male Cbfβ^f/fAggrecan-CreER^T mice. (F, G) Quantification of D and E, n=3. The results are presented as the mean ± SD. **, p<0.01; ***, p<0.001.