RNA-sequencing analysis of Cbfβ-deficient mice hip articular cartilage shows altered TGFβ, Wnt, and Hippo signaling pathways. (A) The volcano plot showed differentially expressed genes (DEGs). Hip articular cartilages from 3-month-old female Cbfβf/fAggrecan-CreERT mice induced by vehicle or TMX. (B-C) Gene Ontology (GO) functional clustering of the top upregulated biological process (BP) in hip articular cartilages from 3-month-old female Cbfβ-deficient mice. (C) GO functional clustering of the top downregulated BP. (D) Heatmap for Hippo signaling related gene expression in hip articular cartilage of 3-month-old Cbfβf/fAggrecan-CreERT mice. (1) Male, Vehicle, hip articular cartilage, (2) Male, TMX, hip articular cartilage, (3) Female, Vehicle, hip articular cartilage, (4) Female, TMX, hip articular cartilage. (E) Heatmap for Wnt signaling-related gene expression in hip articular cartilage of 3-month-old Cbfβf/fAggrecan-CreERT mice. (F) Heatmap for TGFβ signaling-related gene expression in hip articular cartilage of 3-month-old Cbfβf/fAggrecan-CreERT mice.