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. 2024 Mar 11;20(6):1965–1977. doi: 10.7150/ijbs.90250

Figure 5.

Figure 5

Cbfβ deletion in articular cartilage resulted in altered key genes in Hippo/Yap, TGFβ/Smad, and Wnt/β-catenin signaling pathways in vivo. (A-E) IF staining of Yap, active β-Catenin, TCF4, TGFβ1, and p-Smad2/3 in knee articular cartilage from 4.5-month-old male Cbfβf/fAggrecan-CreERT mice induced by vehicle or TMX. (F) Quantification data analysis of A-E, n=3. (G) Western blot data show the protein levels changes of Sox9, Col2α1, and active β-Catenin in male and female mice hip articular cartilages. The results are presented as the mean ± SD. *, p<0.05; **, p<0.01; ***, p<0.001.