Table 1.

Definitions.

Incident cases of T2DM	1. A diabetes diagnosis of T2DM or unspecified diabetes diagnosis made on two different days within 24 months (diagnosis dates ≥14 days apart) 2. A prescription for metformin or glucagon-like peptide-1 (GLP1) agonists and a T2DM or unspecified diabetes diagnosis on any encounter (activities < 14 days apart). 3. A prescription for an antidiabetic agent a) alpha-glucosidase inhibitors, b) amylin analogs, c)anti-diabetic agent combinations including those with metformin; d)insulin among non-pregnant women,6 e) meglitinides, f) sodium glucose cotransporter 2 (SGLT2) inhibitors, g) sulfonylureas, h) thiazolidinediones, and/or i) Dipeptidyl peptidase-4 (DDP-4) inhibitors 4) Lab results a) hemoglobin A1c lab result ≥6.5% or b) fasting plasma glucose ≥126 mg/dl, or c) i) random glucose ≥200 mg/dl on two different days within 24 months (diagnosis dates ≥ 14 days apart), or ii) random glucose ≥ 250 mg/dl, or iii) random glucose ≥ 200 mg/dl and a T2DM or unspecified diabetes diagnosis on any encounter (activities < 14 days apart).
Obesity	1. An obesity diagnosis 2. At least one body mass index (BMI) ≥ 30
BMI	Underweight, <18.5 kg/m2 Normal, 18.5 ≤ BMI < 25 kg/m2 Overweight, 25 ≥ BMI < 30 kg/m2 Obesity I, 30 ≥ BMI < 35 Obesity II, 35 ≤ BMI < 40 kg/m2 Obesity III, ≥ 40 kg/m2
Hypertension/High Blood Pressure	1. Two hypertension diagnoses (≥14 days apart) 2. A hypertension diagnosis and a hypertension medication prescription a) angiotensin-converting enzyme inhibitors (ACE), b) angiotensin II receptor blockers (ARB), c) beta blockers, d) calcium channel blocks, and/or e) diuretics 3. A hypertension diagnosis and a) systolic blood pressure average ≥ 140 (if at least two results ≥ 14 days apart), or b) diastolic blood pressure average ≥ 90 (if at least two results ≥ 14 days apart)
Prediabetes/Elevated Glycemia	1. A prediabetes diagnosis 2. Lab results a) hemoglobin A1c lab result ≥5.7% and <6.5% or b) fasting plasma glucose ≥100 mg/dL and <126 mg/dL
Elevated Lipids	1. An elevated lipids diagnosis 2. A prescription for elevated lipids medication a) statins or statin combinations b) fibrates c) niacin d) bile acid sequestrates, and/or e) other lipid-modifying agents 3. Lab results a) triglyceride level ≥250 mg/dL b) HDL <40 mg/dL for males and <50 mg/dL for females. non-HDL value ≥160 mg/dL
Depression	A diagnosis of depression, including: a) major depressive disorder, or b) depression (mild, moderate, severe, endogenous, recurrent, single episode), or c) chronic depressive personality disorder, or d) major depressive affective disorder, or e) cyclothymic disorder, or f) dysthymia, or g) mixed anxiety and depressive disorder
History of Tobacco Use		1) A diagnosis of: a) tobacco dependence syndrome, or b) tobacco abuse, or c) tobacco user, or d) personal history of tobacco use, or e) nicotine dependence, or 2) Text denoting current tobacco user or quit smoking in Observation table, or 3) Treatment for tobacco use in Procedure table, or 4) A prescription for nicotine or varenicline
Family History of Diabetes		1. A diagnosis of family history of diabetes, or 2. A record in the Observation table denoting family history of diabetes

BMI = body mass index; HDL = high density lipoprotein; T2DM = type 2 diabetes