Fig. 5.

Full mediation models for (A) Hypothalamus-rPoCG rsFC, PSQI, and Depression Problems, and (B) Hypothalamus-rPoCG rsFC, PSQI, and Anxiety Problems in smokers. For each, the mediation effects were assessed for all six models and evaluated at a corrected threshold p = 0.05/6 = 0.0083. The Θ values are standardized coefficients. The mediation p values are for the path “a × b” (see Methods). *Not significant at the corrected threshold. The statistics of all mediation models are summarized in Supplementary Table S4.