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. Author manuscript; available in PMC: 2024 Apr 11.
Published in final edited form as: J Control Release. 2023 Jul 31;361:53–63. doi: 10.1016/j.jconrel.2023.07.040

Fig. 2.

Fig. 2.

Schematic diagram of physiologically based pharmacokinetic (PBPK) model for NPs in (A) tumor-bearing mice intravenously (IV) administrated with AuNPs and various inorganic and organic nanomaterials. (B) This PBPK model consists of eight compartments including plasma, lungs, liver, kidneys, spleen, brain, muscle, remaining tissues (i.e., pooled other tissues) and tumors. (C) Except plasma and brain, each compartment was divided into three major parts: capillary blood, interstitium, and endocytic or phagocytic cells (PCs), or tumor cells (TCs).